Heart failure progression monitoring based on lv conduction pattern and morphology trends

ABSTRACT

Computer implemented methods, devices and systems for monitoring a trend in heart failure (HF) progression are provided. The method comprises sensing left ventricular (LV) activation events at multiple LV sensing sites along a multi-electrode LV lead. The activation events are generated in response to an intrinsic or paced ventricular event. The method implements program instructions on one or more processors for automatically determining a conduction pattern (CP) across the LV sensing sites based on the LV activation events, identifying morphologies (MP) for cardiac signals associated with the LV activation events and repeating the sensing, determining and identifying operations, at select intervals, to build a CP collection and an MP collection. The method calculates an HF trend based on the CP collection and MP collection and classifies a patient condition based on the HF trend to form an HF assessment.

REFERENCE TO RELATED APPLICATIONS

The present application is a continuation application of, and claimspriority to, U.S. application Ser. No. 16/740,553, Titled “HEART FAILUREPROGRESSION MONITORING BASED ON LV CONDUCTION PATTERN AND MORPHOLOGYTRENDS” which was filed on 13 Jan. 2020, which is a continuationapplication of U.S. application Ser. No. 15/963,836, Titled “HEARTFAILURE PROGRESSION MONITORING BASED ON LV CONDUCTION PATTERN ANDMORPHOLOGY TRENDS” which was filed on Apr. 26, 2018 (now U.S. Pat. No.10,582,866, issued 10 Mar. 2020), the complete subject matter of eachare expressly incorporated herein by reference in their entirety.

BACKGROUND

Embodiments herein relate to tracking trends in left ventricularconduction patterns and morphology in connection with monitoring heartfailure progression.

Implantable medical devices (IMD) provide various types of electricalstimulation, such as in connection with delivering pacing therapy to oneor more select chambers of the heart. An IMD may provide both unipolarand bipolar pacing and/or sensing configurations. In the unipolarconfiguration, the pacing pulses are applied (or responses are sensed)between an electrode carried by the lead and a case of the pulsegenerator or a coil electrode of another lead within the heart. In thebipolar configuration, the pacing pulses are applied (or responses aresensed) between a pair of electrodes carried by the same lead. IMD's mayimplement single-chamber or dual-chamber functionality. Recently, IMDshave been introduced that stimulate multiple sites in the same chamber,termed multisite stimulation systems or multi-purpose pacing systems.

Recently, multi-point pacing (MPP) technology has enabled pacing atmultiple left ventricular (LV) sites to improve synchrony in cardiacresynchronization therapy (CRT) patients.

However, over time, at least some CRT patients experience a progressionof heart failure disease. Today, heart failure disease progression inCRT patients is generally only monitored in a limited manner, such asduring in clinic follow-up visits. During an in clinic visit,echocardiography signals are collected to measure a patient'shemodynamics and/or electrocardiography (ECG) signals are collected tomeasure the patient's electrical synchrony. In clinic visits provide asingle time point snapshot of a patient's cardiovascular status. Inclinic visits are infrequent and in some instances, may be performedonly after a heart failure disease has progressed to a significant levelrequiring a patient to be hospitalized. Current systems for monitoringheart failure (HF) disease progression do not afford daily trends in thedisease progression.

SUMMARY

In accordance with embodiments herein, a computer implemented method formonitoring a trend in heart failure (HF) progression is provided. Themethod comprises sensing left ventricular (LV) activation events atmultiple LV sensing sites along a multi-electrode LV lead. Theactivation events are generated in response to an intrinsic or pacedventricular event. The method implements program instructions on one ormore processors for automatically determining a conduction pattern (CP)across the LV sensing sites based on the LV activation events,identifying morphologies (MP) for cardiac signals associated with the LVactivation events and repeating the sensing, determining and identifyingoperations, at select intervals, to build a CP collection and an MPcollection. The method calculates an HF trend based on the CP collectionand MP collection and classifies a patient condition based on the HFtrend to form an HF assessment.

Optionally, the calculating the HF trend may comprise calculating aCP-based trend indicator by applying an AT metric to the CP collectionand may comprise calculating an MP-based trend indicator by applying anMP metric to the MP collection. The applying the AT metric may compriseapplying at least one of a dyssynchrony metric, conduction nonuniformitymetric, conduction velocity metric, fastest conduction pathway metric orchronotropic incompetence metric. The applying the MP metric maycomprise applying at least one of an electrical synchrony metric,electrically viable local tissue metric, pacing depolarization integralmetric, slope based electrical excited ability metric or templatematching score metric. The applying the MP metric may comprise applyingthe MP metric in connection with interelectrode differences between themorphologies associated with different LV sensing sites.

Optionally, the method may compare the CP-based and MP-based trendindicators to corresponding thresholds. The method may classify thepatient condition to form the HF assessment based on the comparing. Thecalculating the HF trend may comprises calculating a CP-based trendindicator and an MP-based trend indicator. The classifying may comprisecomparing the CP-based and MP-based trend indicators to correspondingthresholds to classify the patient condition as one of improved,deteriorated or no change. The sensing, determining and identifyingoperations may be performed by an implantable medical device, while atleast a portion of the calculating and classifying operations areperformed by at least one of an external device and a remote server. Thesensing, determining, identifying, calculating and classifyingoperations may be performed by an implantable medical device. The methodmay further comprising transmitting the HF assessment from theimplantable medical device to at least one of an external device and aremote server.

In accordance with embodiments herein, a computer implemented method isprovided. The computer implemented method comprises monitoring a trendin heart failure (HF) progression in connection with left ventricular(LV) activation events sensed over a select interval, at multiple LVsensing sites along a multi-electrode LV lead. There the activationevents are generated in response to an intrinsic or paced ventricularevent. The method implements program instructions on one or moreprocessors for automatically, obtains a conduction pattern (CP)collection of conduction patterns across the LV sensing sites, and amorphology (MP) collection of MPs for cardiac signals associated withthe LV activation events. The method calculates an HF trend based on theCP collection and MP collection and classifies a patient condition basedon the HF trend to form an HF assessment.

Optionally, the calculating the HF trend may comprise automaticallycalculating, at a local external device and/or a remote server aCP-based trend indicator by applying an activation time (AT) metric tothe CP collection and an MP-based trend indicator by applying an MPmetric to the MP collection. The applying the AT metric may compriseapplying at least one of a dyssynchrony metric, conduction nonuniformitymetric, conduction velocity metric, fastest conduction pathway metric orchronotropic incompetence metric. The applying the MP metric maycomprise applying at least one of an electrical synchrony metric,electrically viable local tissue metric, pacing depolarization integralmetric, slope based electrical excited ability metric or templatematching score metric.

Optionally, the obtaining the CP collection and MP collection maycomprise at least one of i) accessing memory of an external device orremote server that stores the CP collection and MP collection, ii)receiving the CP collection and MP collection over a wirelesscommunications link between an implantable medical device and a localexternal device, or iii) receiving the CP collection and MP collectionat a remote server over a network connection. The method may sense theLV activation events at the multiple LV sensing sites along themulti-electrode LV lead. The method may determine the conduction patternacross the LV sensing sites based on the LV activation events. Themethod may identify MPs for cardiac signals associated with the LVactivation events and may repeat the sensing, determining andidentifying operations, at select intervals, to build the CP collectionand the MP collection.

In accordance with embodiments herein, a system for monitoring a trendin heart failure (HF) progression is provided. The system comprises amulti-electrode LV lead to sense left ventricular (LV) activation eventsat multiple LV sensing sites along the multi-electrode LV lead. Theactivation events are generated in response to an intrinsic or pacedventricular event. Memory stores program instructions. One or moreprocessors that, when executing the program instructions, are configuredto automatically: determine a conduction pattern (CP) across the LVsensing sites based on the LV activation events, identify morphologies(MP) for cardiac signals associated with the LV activation events,repeat the sensing, determining and identifying operations, at selectintervals, to build a CP collection and an MP collection, calculate anHF trend based on the CP collection and MP collection and classify apatient condition based on the HF trend to form an HF assessment.

Optionally, the one or more processors may be configured to calculatethe HF trend by calculating a CP-based trend indicator by applying anactivation time (AT) metric to the CP collection. The one or moreprocessors may be configured to calculate the HF trend by calculating anMP-based trend indicator by applying an MP metric to the MP collectionand calculating the HF trend based on the CP-based and MP-based trendindicators. The one or more processors may be configured to calculatethe HF trend by comparing current and historic CP-based trend indicatorsand comparing current and historic MP-based trend indicators.

Optionally, the one or more processors may be configured to calculatethe HF trend by calculating a CP-based trend indicator and an MP-basedtrend indicator. The classifying may comprise comparing the CP-based andMP-based trend indicators to corresponding thresholds to classify thepatient condition as one of improved, deteriorated or no change. Animplantable medical device (IMD) may be coupled to the multi-electrodeLV lead. A local external device may be configured to wirelesslycommunicate with the IMD. The local external device may be configured tocommunicate over a network with a remote server. The one or moreprocessors may comprise at least a first processor housed within the IMDand configured to perform at least the determining and identifyingoperations.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates an implantable medical device (IMD) in electricalcommunication with multiple leads implanted into a patient's heart fordelivering multi-chamber stimulation and sensing cardiac activityaccording to an embodiment.

FIG. 2 illustrates the one or more processors utilizing the arrivaltimes to determine a conduct pattern (CP) across the LV sensing sites inaccordance with embodiments herein.

FIG. 3A illustrates a process for calculating an HF trend based on theCP collection and morphology (MP) collection recorded in connection withthe operations of FIG. 2 in accordance with an embodiment herein.

FIG. 3B illustrates a process for classifying a patient condition basedon trend indicators to form an HF assessment and to providenotifications of the HF assessment in accordance with embodimentsherein.

FIG. 4A illustrates an example of a relation between RV-LV conductiondelay, left atrial pressure (LAP) during rapid pacing induced heartfailure in accordance with embodiments herein.

FIG. 4B illustrates a graph plotting multiple data streams (e.g.,cardiac signals) measured in connection with different sensing sites inaccordance with embodiments herein.

FIG. 4C illustrates examples of conduction patterns that may bedetermined at different points in time for an individual patient inaccordance with embodiments herein.

FIG. 4D illustrates examples of site-to-site (STS) relative spacing fordistal portions of an LV lead that may be shaped in accordance withembodiments herein.

FIG. 4E illustrates an example of an LV electrode combination and awaveform propagating from the distal and to the proximal end of the LVlead in accordance with embodiments herein.

FIG. 4F illustrates graphs simulating electrocardiogram (EGM)morphologies for a collection of events that were recorded over timeduring HF induction in connection with rapid pacing by an IMD inaccordance with embodiments herein.

FIG. 5 illustrates a simplified block diagram of internal components ofthe IMD (e.g., IMD) according to an embodiment.

FIG. 6 illustrates a functional block diagram of an external device thatis operated in accordance with embodiments herein.

FIG. 7 illustrates a system in accordance with embodiments herein.

DETAILED DESCRIPTION

It will be readily understood that the components of the embodiments asgenerally described and illustrated in the Figures herein, may bearranged and designed in a wide variety of different configurations inaddition to the described example embodiments. Thus, the following moredetailed description of the example embodiments, as represented in theFigures, is not intended to limit the scope of the embodiments, asclaimed, but is merely representative of example embodiments.

Reference throughout this specification to “one embodiment” or “anembodiment” (or the like) means that a particular feature, structure, orcharacteristic described in connection with the embodiment is includedin at least one embodiment. Thus, appearances of the phrases “in oneembodiment” or “in an embodiment” or the like in various placesthroughout this specification are not necessarily all referring to thesame embodiment.

Furthermore, the described features, structures, or characteristics maybe combined in any suitable manner in one or more embodiments. In thefollowing description, numerous specific details are provided to give athorough understanding of embodiments. One skilled in the relevant artwill recognize, however, that the various embodiments can be practicedwithout one or more of the specific details, or with other methods,components, materials, etc. In other instances, well-known structures,materials, or operations are not shown or described in detail to avoidobfuscation. The following description is intended only by way ofexample, and simply illustrates certain example embodiments.

The methods described herein may employ structures or aspects of variousembodiments (e.g., systems and/or methods) discussed herein. In variousembodiments, certain operations may be omitted or added, certainoperations may be combined, certain operations may be performedsimultaneously, certain operations may be performed concurrently,certain operations may be split into multiple operations, certainoperations may be performed in a different order, or certain operationsor series of operations may be re-performed in an iterative fashion. Itshould be noted that other methods may be used in accordance with anembodiment herein. Further, wherein indicated, the methods may be fullyor partially implemented by one or more processors of one or moredevices or systems. While the operations of some methods may bedescribed as performed by the processor(s) of one device, additionally,some or all of such operations may be performed by the processor(s) ofanother device described herein.

Embodiments may be implemented in connection with one or moreimplantable medical devices (IMDs). Non-limiting examples of IMDsinclude one or more of neurostimulator devices, implantable leadlessmonitoring and/or therapy devices, and/or alternative implantablemedical devices. For example, the IMD may represent a cardiac monitoringdevice, pacemaker, cardioverter, cardiac rhythm management device,defibrillator, neurostimulator, leadless monitoring device, leadlesspacemaker and the like. For example, the IMD may include one or morestructural and/or functional aspects of the device(s) described in U.S.Pat. No. 9,333,351 “Neurostimulation Method And System To Treat Apnea”and U.S. Pat. No. 9,044,610 “System And Methods For Providing ADistributed Virtual Stimulation Cathode For Use With An ImplantableNeurostimulation System”, which are hereby incorporated by reference.Additionally or alternatively, the IMD may include one or morestructural and/or functional aspects of the device(s) described in U.S.Pat. No. 9,216,285 “Leadless Implantable Medical Device Having RemovableAnd Fixed Components” and U.S. Pat. No. 8,831,747 “LeadlessNeurostimulation Device And Method Including The Same”, which are herebyincorporated by reference. Additionally or alternatively, the IMD mayinclude one or more structural and/or functional aspects of thedevice(s) described in U.S. Pat. No. 8,391,980 “Method And System ForIdentifying A Potential Lead Failure In An Implantable Medical Device”and U.S. Pat. No. 9,232,485 “System And Method For SelectivelyCommunicating With An Implantable Medical Device”, which are herebyincorporated by reference.

In accordance with embodiments herein, methods and systems are describedto track long-term patient response to IMD therapies, such as CRTtherapies. The long-term patient response tracks changes in (a) RV andLV electrode activation conduction patterns during intrinsic and/orpaced conduction, and/or (b) EGM morphologies. For example, thelong-term tracking may search for gradual changes that are expected inresponse to LV reverse remodeling. Embodiments herein identifydifferences in activation time across the 4 LV electrodes (D1, M2, M3,P4) during intrinsic RV-LV conduction over a select period of time. Forexample, the methods and systems herein may collect activation eventsdaily, weekly, monthly and the like. The RV-LV activation times for theactivation events sensed at the 4 LV electrodes can be averaged,wirelessly transmitted from an IMD to a local external device anduploaded over a wide area network to a remote medical network server,such as the Merlin.net™ network. The RV-LV activation times may be usedto define conduction patterns indicative of a manner in which electricalwave fronts propagate through the left ventricular wall tissue. Overtime, the conduction patterns change, thereby providing long-term trendsthat embodiments herein utilized to track various patient conditions,such as reverse remodeling. Additionally, embodiments herein collect andsave daily averages of the EGM morphologies at the LV electrodes duringpaced/intrinsic RV-LV conduction. The EGM morphologies are tracked in asimilar manner to provide trends over time.

Terms

The term “LV sensing site”, as used herein, refers to the location of anLV electrode that at least partially defines a sensing vector or channelover which the delivered pacing pulse is sensed. For example, themultiple LV sensing sites correspond to the locations of the LVelectrodes, such as D1, M2, M3, and P4 of a quadripolar LV lead. In anembodiment, the IMD senses along at least four sensing vectors, whereeach sensing vector utilizes a sensing cathode electrode in the leftventricle. The sensing vectors associated with the LV sensing sites maybe unipolar vectors D1-CAN, M2-CAN, M3-CAN, and P4-CAN, where the CANrepresents the anode electrode and D1, M2, M3 and P4 represent thecathode electrode. The pacing pulse is delivered at a RV pacing site andsensed at various LV sensing sites. This configuration may be referredto as RV pace-LV sense. Optionally, sensing vectors other than unipolarvectors may be used, such as D1-RV coil. In accordance with at leastsome embodiments, the sensing vectors are assigned to exclude LVelectrodes as anodes and limit the LV electrodes to be cathodes.

The term “pacing site” refers to a location of a cathode that is used todeliver a pacing pulse along a pacing vector. For example, an RV pacingpulse may be delivered at the RV tip electrode or the RV ring electrode,along a pacing vectors RV tip to RV coil, or RV ring to RV coil,respectively. Optionally, the pacing vector may be unipolar between anRV cathode and the CAN. As another example, an RA pacing site may be atthe atrial tip electrode or the atrial ring electrode, along the pacingvectors from the respective electrodes to the SVC coil or to the CAN.

FIG. 1 illustrates an implantable medical device (IMD) 100 in electricalcommunication with multiple leads implanted into a patient's heart 105for delivering multi-chamber stimulation and sensing cardiac activityaccording to an embodiment. The IMD 100 may be a dual-chamberstimulation device, including an IMD, capable of treating both fast andslow arrhythmias with stimulation therapy, including cardioversion,defibrillation, and pacing stimulation, including CRT. Optionally, theIMD 100 may be configured for multi-site left ventricular (MSLV) pacing,which provides pacing pulses at more than one site within the LV chambereach pacing cycle. To provide atrial chamber pacing stimulation andsensing, IMD 100 is shown in electrical communication with a heart 105by way of a left atrial (LA) lead 120 having an atrial tip electrode 122and an atrial ring electrode 123 implanted in the atrial appendage 113.IMD 100 is also in electrical communication with the heart 105 by way ofa right ventricular (RV) lead 130 having, in this embodiment, aventricular tip electrode 132, an RV ring electrode 134, an RV coilelectrode 136, and a superior vena cava (SVC) coil electrode 138. The RVlead 130 is transvenously inserted into the heart 105 so as to place theRV coil electrode 136 in the RV apex, and the SVC coil electrode 138 inthe superior vena cava. Accordingly, the RV lead 130 is capable ofreceiving cardiac signals and delivering stimulation in the form ofpacing and shock therapy to the right ventricle 114 (also referred to asthe RV chamber).

To sense left atrial and ventricular cardiac signals and to provide leftventricle 116 (e.g., left chamber) pacing therapy, IMD 100 is coupled toa multi-pole LV lead 124 designed for placement in the “CS region.” Asused herein, the phrase “CS region” refers to the venous vasculature ofthe left ventricle, including any portion of the coronary sinus (CS),great cardiac vein, left marginal vein, left posterior ventricular vein,middle cardiac vein, and/or small cardiac vein or any other cardiac veinaccessible by the coronary sinus. In an embodiment, an LV lead 124 isdesigned to receive atrial and ventricular cardiac signals and todeliver left ventricular pacing therapy using a set of multiple LVelectrodes 126 that includes electrodes 126 ₁, 126 ₂, 126 ₃, and 126 ₄(thereby providing a multipolar or multi-pole lead). The LV lead 124also may deliver left atrial pacing therapy using at least an LA ringelectrode 127 and shocking therapy using at least an LA coil electrode128. In alternate embodiments, the LV lead 124 includes the LVelectrodes 126 ₁, 126 ₂, 126 ₃, and 126 ₄, but does not include the LAelectrodes 127 and 128. The LV lead 124 may be, for example, theQuartet™ LV pacing lead developed by St. Jude Medical Inc.(headquartered in St. Paul, Minn.), which includes four pacingelectrodes on the LV lead. Although three leads 120, 124, and 130 areshown in FIG. 1, fewer or additional leads with various numbers ofpacing, sensing, and/or shocking electrodes may optionally be used. Forexample, the LV lead 124 may have more or less than four LV electrodes126.

The LV electrode 126 ₁ is shown as being the most “distal” LV electrodewith reference to how far the electrode is from the left atrium 118. TheLV electrode 126 ₄ is shown as being the most “proximal” LV electrode126 to the left atrium 118. The LV electrodes 126 ₂ and 126 ₃ are shownas being “middle” LV electrodes, between the distal and proximal LVelectrodes 126 ₁ and 126 ₄, respectively. Accordingly, so as to moreaptly describe their relative locations, the LV electrodes 126 ₁, 126 ₂,126 ₃, and 126 ₄ may be referred to respectively as electrodes D1, M2,M3, and P4 (where “D” stands for “distal”, “M” stands for “middle”, and“P” stands from “proximal”, and the numbers are arranged from mostdistal to most proximal, as shown in FIG. 1). Optionally, more or fewerLV electrodes may be provided on the lead 124 than the four LVelectrodes D1, M2, M3, and P4.

The LV electrodes 126 are configured such that each electrode may beutilized to deliver pacing pulses and/or sense pacing pulses (e.g.,monitor the response of the LV tissue to a pacing pulse). In a pacingvector or a sensing vector, each LV electrode 126 may be controlled tofunction as a cathode (negative electrode). Pacing pulses may bedirectionally provided between electrodes to define a pacing vector. Asexplained herein, combinations of LV electrodes 126 are paired with oneanother to operate as a common virtual electrode, such as a commonvirtual cathode, when delivering pacing therapies. In a pacing vector, agenerated pulse is applied to the surrounding myocardial tissue throughthe cathode. The electrodes that define the pacing vectors may beelectrodes in the heart 105 or located externally to the heart 105(e.g., on a housing/case device 140). For example, the housing/casedevice 140 may be referred to as the CAN 140 and function as an anode inunipolar pacing and/or sensing vectors. The LV electrodes 126 may beused to provide various different vectors. Some of the vectors areintraventricular LV vectors (e.g., vectors between two of the LVelectrodes 126), while other vectors are interventricular vectors (e.g.,vectors between an LV electrode 126 and the RV coil 136 or anotherelectrode remote from the left ventricle 116). Below is a list ofexemplary bipolar sensing vectors with LV cathodes that may be used forsensing using the LV electrodes D1, M2, M3, and P4 and the RV coil 136.In the following list, the electrode to the left of the arrow is assumedto be the cathode, and the electrode to the right of the arrow isassumed to be the anode.

D1→RV coil

M2→RV coil

M3→RV coil

P4→RV coil

D1→M2

D1→P4

M2→P4

M3→M2

M3→P4

P4→M2

It is recognized that various other types of leads and IMDs may be usedwith various other types of electrodes and combinations of electrodes.The foregoing electrode types/combinations are provided as non-limitingexamples. Further, it is recognized that utilizing an RV coil electrodeas an anode is merely one example. Various other electrodes may beconfigured as the anode electrode. Below is a list of exemplary bipolarpacing vectors with LV cathodes that may be used for pacing using the LVelectrodes D1, M2, M3, and P4 and the RV coil 136. In the followinglist, the electrodes to the left of the arrow are assumed to becathodes, and the electrode to the right of the arrow is assumed to bethe anode.

D1→RV coil (or CAN)+M2→RV coil (or CAN)

M2→RV coil (or CAN)+M3→RV coil (or CAN)

M3→RV coil (or CAN)+M4→RV coil (or CAN)

M2→RV coil (or CAN)+M3→RV coil (or CAN)+P4→RV coil (or CAN)

D1→RV coil (or CAN)+M2→RV coil (or CAN)+M3→RV coil (or CAN)

It is noted that the preceding list is only a subset of the availablepacing and sensing vectors for use with the IMD 100. Further, whendelivering a series of pacing pulses, one of the above pacing vectors isused for at least the first pacing pulse in the series. Other pacingvectors may be used for subsequent pulses in the series of pacingpulses. Furthermore, additional pacing pulses may be generated in otherchambers of the heart, such as the right ventricle.

Conduction Pattern

Activation times can provide an accurate surrogate for heart failurestatus. For example, one trend indicator may relate to RV-LV conductiondelay.

FIG. 4A illustrates an example of a relation between RV-LV conductiondelay, left atrial pressure (LAP) during rapid pacing induced heartfailure. FIG. 4A plots a time period between January and November 2007along the horizontal axis, RV-LV delay in milliseconds along the leftvertical axis and left atrial pressure in millimeters of mercury alongthe right vertical axis. The RV-LV delay 402 is shown in a solid line,while the LAP 404 is shown in a dashed line. The grade regions indicaterapid pacing time periods 406-408 during which a patient experiencedinduction of heart failure. The induced heart failure occurred duringtime periods in which the patient's implantable medical device wasprogram to provide rapid pacing. The rapid pacing functionality wasturned off during the intervals 409-411. During the intervals 409-411,the patient experienced recovery or reverse heart modeling away from anHF condition.

As shown in FIG. 4A, the RV-LV delay 402 and the LAP 404 experiencedspikes during the rapid pacing time periods 406-408. The RV-LV delay 402and the LAP 404 dropped to substantially lower levels during theintervals 409-411 during which rapid pacing was turned off. From thetrends exhibited in FIG. 4A, it can be seen that RV-LV conduction delayincreases over time during the induction of HF. Thus, the conductiondelay between the RV and LV provides a good surrogate for HF status. Thecorrelation between HF progression and RV-LV conduction time can beextrapolated to the conduction times and conduction pattern across theRV electrode and all 4 LV electrodes, for a quadripolar LV lead (e.g.,Quartet®). Similarly, the changes in conduction non-uniformity inresponse to remodeling (or reverse remodeling) can be tracked and viewedas long-term trends to follow HF progression over time. In accordancewith embodiments herein, changes in the electrical conduction patternsare identified and utilized to classify heart failure remodeling.

HF Progression Monitoring

Conduction patterns and EGM morphologies generally uniquely correspondto different stimulus origins, myocardial structures, and the underlyingelectrophysiology. During intrinsic RV-LV conduction, the stimulusorigin may generally remain the same over time, whereas the myocardialstructure and underlying electrophysiology will change as ventricularremodeling progresses or reverses. The changes in myocardial structureand underlying electrophysiology generally represent electromechanicalchanges. Long-term electromechanical changes can be captured over weeksand months by collecting conductions patterns and tracking gradualalterations in the RV-LV activation pattern across the 4 LV electrodes.The following discussion describes (A) example activation patternmetrics associated with conduction patterns over HF progression, (B)morphology metrics associated with different EGM morphologies over HFprogression, and (C) the overall assessment of HF by identifying trendsin the conduction patterns and morphologies.

FIGS. 2 and 3A-3B illustrate a process for monitoring trends and heartfailure progression in accordance with embodiments herein. The process200 may be performed in whole or in part by the IMD 100. Optionally, alocal external device and/or remote server may perform all or portionsof the processes described herein utilizing activation events sensed bythe IMD 100. In various embodiments, certain aspects of the process 200may be omitted or added, certain aspects may be combined, certainaspects may be performed simultaneously, certain aspects may beperformed concurrently, certain aspects may be split into multipleaspects, certain aspects may be performed in a different order, orcertain aspects or series of aspects may be re-performed in an iterativefashion. In general, it is contemplated that the process of FIGS. 2 and3A-3B will be performed in an unsupervised out of clinic environment,however, the process may be performed in whole or in part in a clinicunder the supervision of a clinician.

At 202, an intrinsic ventricular event occurs or a paced ventricularevent (e.g., pacing pulse) is delivered from at least one RV or RApacing site. For a paced event, the pacing pulse is generated by thepulse generator 170 and/or the pulse generator 172, depending on thetherapy pacing site selected. The pacing pulse may be delivered by themicrocontroller 160 by sending a control signal to one or both pulsegenerators 170, 172 that identifies the pacing vector, the electricaloutput, the timing, and the like. The pulse generator 170 and/or 172 inresponse generates an electrical potential at one or both electrodesthat define a selected pacing vector, resulting in a potentialdifference between the electrodes that induces a depolarization wave inthe surrounding heart tissue. The depolarization wave propagates along awave front that varies in shape, timing and velocity based on, amongother things, a health of the heart wall.

At 204, LV activation events are sensed at corresponding LV sensingsites. For example, when four LV electrodes are utilized as separatesensing sites, four LV activation events are sensed. In the presentexample, a set of four LV activation events are generated in response toa single paced or intrinsic event. The LV activation events are detectedat individual LV sensing sites as the propagating depolarization wavefront crosses the corresponding LV electrodes.

In an embodiment, the LV activation events are sensed by at least onesensor. For example, the sensor may be the ventricular sensing circuit184, which includes an amplifier. For example, sensed electricalactivity (e.g., voltage and/or current) at each electrode in a sensingvector may be routed as signals through the electrode configurationswitch 174 to the ventricular sensing circuit 184. The ventricularsensing circuit 184 may amplify, convert, and/or digitize the receivedsignals before forwarding the signals to the microcontroller 160 forrecordation and analysis of the data. Optionally, various other sensorsand/or sensing circuits may be used to sense the LV activation eventsinstead of or in addition to the ventricular sensing circuit 184.

An optional operation is illustrated at 205. At 205, a transceiver of anIMD may transmit the activation events as sensed to an external devicewhich may then convey the activation events to a remote server. Theinformation transmitted at 205 may include digitize representations of araw analog sensed signals as sensed at each LV sensing site. Forexample, a transmission may include a set of digitized sensed signalsfor a predetermined period of time (e.g., a number of milliseconds),where each digitized sensed signal corresponds to a different LV sensingelectrode. Optionally, the operation at 205 may be omitted entirely.

At 206, one or more processors measure arrival times of the LVactivation events for corresponding LV sensing sites (e.g., by theconduction pattern detector 163 and/or CPU 602). The arrival times(e.g., conduction delays) may correspond to a conduction time fromdelivery of the pacing pulse until sensing of the corresponding LVactivation event. For example, arrival times may be measured byrecording the time (e.g., designated as time To) that a pacing pulse isdelivered at an RV site, recording the times (e.g., designated as timesT_(D1), T_(M2), T_(M3), T_(P4)) of the LV activation events at each ofthe LV sensing sites, and subtracting the time of the pacing pulse fromthe times of the LV activation events (e.g., T₀−T_(D1)). Optionally, thearrival times may be measured using an internal timer (associated witheach sensing site for each sensing circuit) by starting the timer whenthe pacing pulse is delivered and stopping the timer when each LVactivation event occurs to determine the arrival time of each respectiveLV activation event. Optionally, in connection with an intrinsic event,the arrival times may be measured using an internal timer by startingthe timer when the intrinsic event is sensed at an RV sensing site andstopping the timer when each LV activation event occurs to determine thearrival time of each respective LV activation event. As an example, ifit takes 60 ms after an RV pacing pulse (or intrinsic RV event) for thesensor (e.g., sensing circuit 184) to detect an LV activation event atan LV sensing site, then the arrival time for that LV sensing site is 60ms. The arrival times at the different LV sensing sites may vary due tothe difference in locations of the LV electrodes relative to the cathodeat the RV pacing site. Due to the different relative locations, thepropagation wave may reach some LV sensing sites sooner than othersensing sites, resulting in a shorter arrival time.

Optionally, the arrival times may be measured by the external device 600and/or a remote server. In order to afford external measurement, the IMD100 may convey raw sensed data to a local remote device and/or remoteserver. For example, the local remote device may be a smart phone,tablet device, laptop computer, Merlin™ programmer (developed by St.Jude Medical, Inc.) and the like. The external device and/or remoteserver analyze the raw sensed data and determine the time from the RVpacing or intrinsic marker to LV activation at each of the LV sensingsites (e.g., D1-CAN, M2-CAN, M3-CAN, P4-CAN).

FIG. 4B illustrates a graph 410 plotting multiple data streams (e.g.,cardiac signals) measured in connection with different sensing sites.The data streams are displayed as intracardiac electrogram (IEGM)waveforms representative of the electrical activity in ventriculartissue (measured in mV) over time (measured in ms). The graph 410displays an IEGM waveform 412 associated with an RV electrode and twoIEGM waveforms 414, 416 associated with an LV distal electrode and anadjacent LV electrode, respectively. The three IEGM waveforms 412-416may be representative of the electrical activity sensed along sensingvectors at least partially defined by the respective correspondingelectrodes. The graph 410 displays the waveforms 412-416 verticallyseparated in order to compare the shape of the waveforms 412-416 overtime. It should be recognized that the waveforms 412-416 share a commontime scale but may not share the same electrical activity scale, meaningthat the vertical distance between one waveform from the other waveformsdoes not represent a difference in the measured mV.

The graph 410 illustrates how arrival times of LV activation events maybe measured at operation 206 of process 200 (shown in FIG. 2) as well ashow site-to-site (STS) relative delays may be calculated. For example,each of the sensing vectors may begin sensing for electrical activity attime t₁. At time t₂, an RV pacing pulse is delivered at an RV pacingsite, which is denoted on the graph 410 by an RV pace marker 418. As thedepolarization wave propagates through the myocardial tissue, theactivity sensed at the RV and LV sensing sites are recorded in thewaveforms 412-416. For example, the wave is used for biventricular (BiV)pacing, as the pulse delivered in the right ventricle propagates to theleft ventricle where it is sensed at the LV sensing sites. The LV distalelectrode waveform 414 indicates the presence of an LV activation eventat time t₃, while the LV adjacent electrode waveform 416 indicates an LVactivation event afterwards at time t₄. The LV activation events for theLV distal electrode and the LV adjacent electrode are denoted byactivation event markers 420 and 422, respectively.

As shown in graph 410, the activation event markers 420, 422 representthe midpoint of the negative slope of the R-wave 424, which representsintrinsic ventricular depolarization, or the maximum negative slope ofthe R-wave 424. Optionally, the markers 420, 422 may be located at otherlocations along the R-waves 424 of the waveforms 414, 416, as long asthe location selected is the same for both waveforms 414, 416, forcomparison purposes. For example, the markers 420, 422 optionally may belocated at the starting point of the R-wave 424 (e.g., leftmost locationwith a positive amplitude), the midpoint of the positive slope of theR-wave 424, the point of maximum positive slope, the apex of the R-wave424, the nadir or lowest point of the R-wave 424, and the like. Themarkers 420, 422 are positioned automatically, and the arrival times andSTS relative delays calculated automatically, by the IMD 100, localexternal device and/or remote server without assistance from a clinicianor another third party.

Once the LV activation events 420, 422 are determined, the arrival timesfor each of the LV sensing sites are computed by measuring the timebetween the time of the RV pacing marker 418 and the times of theactivation events 420, 422. For example, the LV activation event 420 forthe LV distal electrode occurs at time t₃, the RV pacing marker 418occurs at time t₂, so the arrival time 426 for the LV sensing site atthe LV distal electrode is the difference between times t₃ and t₂. Asshown in FIG. 4B, that difference was measured to be 93 ms, whichrepresents the arrival time 426 of the LV activation event 420 at the LVdistal sensing site. Likewise, the arrival time 428 for the LVactivation event 422 at the LV proximal sensing site is represented asthe time difference between the event 422 at time t₄ and the pacingpulse at time t₂, which is measured to be 106 ms. Since the arrivaltimes 426, 428 for respective LV distal and proximal sensing sites areknown, the STS relative delay between these two sensing sites may becalculated as the difference between the two times 426, 428. Forexample, as shown in FIG. 4, the STS relative delay (e.g., Δdelay) 440for the combination of the LV distal sensing site and the LV proximalsensing site is 13 ms, calculated by subtracting 93 ms from 106 ms. The13 ms delay 440 represents the time delay from time t₃ to time t₄.

Returning to FIG. 2, at 208, the one or more processors utilizes thearrival times to determine a conduct pattern (CP) across the LV sensingsites. The conduction pattern is saved along with a timestamp indicatinga time at which the conduction pattern was sensed. Additionally oralternatively, other information may be recorded with the conductionpattern. For example, the microcontroller 160 and/or CPU 602 maycalculate a difference between the arrival times for a selectcombination of the adjacent electrodes to obtain a site-to-site (STS)relative delay between the select combination of the adjacent LV sensingsites. For example, STS relative delay_(D1,M2) for the electrodecombination D1+M2 may be calculated by subtracting the arrival timeassociated with the LV sensing site at the D1 electrode from the arrivaltime associated with the LV sensing site at the M2 electrode. Therefore,if the arrival time at sensing site D1 is measured to be 80 ms, and thearrival time at sensing site M2 is 87 ms, the STS relativedelay_(D1, M2) would be the difference, 7 ms. The STS relative delaysmay be calculated by the delay calculation (DC) module 168 within themicrocontroller 160, and/or the CPU 602.

FIG. 4C illustrates examples of conduction patterns that may bedetermined at different points in time for an individual patient. PanelsA-C illustrate examples of conduction patterns during intrinsicconduction demonstrating reverse remodeling. Panel A corresponds to aselect point in time before an IMD is implanted, while panels B and Ccorrespond to select points in time at 3 months post implant and 6months post implant. The panels A-C graphically illustrate schematics orpropagation wave fronts 450-452 to show the pathway of propagationacross the RV and 4 LV electrodes. The propagation wave fronts 450-452differ from one another as the health of the heart wall has changed(exhibits reverse modeling) between the pre-implant, 3 month and 6 monthpoints in time. Panels A-C also illustrate conduction patterns 455-457that are determined at 208. The conduction patterns 455-457 illustratethe order of activation times for the RV and four LV electrodes. Thegradual change in activation pattern of the RV and LV electrodes canhighlight a reduction in electrical dyssynchrony that followsventricular reverse remodeling. The conduction patterns 455-457illustrate the LV sensing site (LV electrode) along the horizontal axisand the activation time along the vertical axis. At pre-implant, thepatient exhibited a large difference in arrival time 460 between theintrinsic or paced event at the RV site and the distal LV_(D1) sensingsite followed by a shorter difference in arrival time 461 between thedistal LV_(D1) and second middle LV_(M2) sensing sites. The third middleLV_(M3) sensing site sensed the conduction pattern 455 (propagation wavefront) an arrival time 462 before the second middle LV sensing siteLV_(M1), while the fourth proximal LV_(P4) sensing site sensed thepropagation wave front a relatively longer arrival time 462 after thethird middle LV_(M3).

The conduction pattern 456, exhibited 3 months after implant, differsfrom the conduction pattern 455 pre-implant. The conduction pattern 456has an arrival time at the third middle LV_(M3) sensing site that doesnot follow the arrival time at the second middle LV_(M2) sensing site,thereby indicating an improvement in the electromechanical properties ofthe local heart tissue in the region between the second and third middleLV_(M2) and LV_(M3) sensing sites. The conduction pattern 457 exhibited6 months after implant shows a healthier myocardial condition ascompared to the conduction pattern 456 exhibited 3 months after implant.In particular, the activation times of the conduction pattern 457 havegenerally even differences in activation time 465-468 there between. Sixmonths after implant, the activation time 469 for LV_(P4) sensing siteoccurred evenly after the activation time 470 for LV_(M3) sensing site,which shows an improvement over the activation times 471, 472 forLV_(P4) and LV_(M3) sensing sites.

FIG. 4D illustrates examples of STS relative spacing for distal portionsof an LV lead that may be shaped in accordance with embodiments herein.Within FIG. 4D, the distal portions 702, 704 and 706 may correspond to acommon lead, but bent in different manners based upon the venous branch.The distal portions 702, 704 and 706 each include LV electrodes P4, M3,M2 and D1. The electrodes P4 and M3 have an STS axial spacing 716. Theelectrodes M3 and M2 have an STS axial spacing 718. The electrodes M2and D1 have an STS axial spacing 720. The distal portion of the LV leadmay be shaped in different manners based upon the venous branch in whichthe lead is placed. For example, the distal portion 706 may bepositioned in a venous branch which maintains the distal portion in arelatively straight manner. Alternatively, the distal portion 704 may bepositioned in a venous branch that slightly bends the distal portion.Alternatively, the distal portion 702 may position in a venous branchthat substantially bends the lead, such as in an S-shape.

When the LV lead is shaped corresponding to the distal portion 706, theSTS axial spacing 716-720 between the electrodes (P4, M3, M2 and D1)along the longitudinal axis of the lead generally may be used as the STSrelative spacing. However, when the LV lead is shaped, corresponding tothe distal portion 702, the axial spacing between the electrodes (P4,M3, M2 and D1) does not necessarily correspond to the actual STSrelative spacing. Instead, the electrodes M2 and D1 may have an STSrelative spacing 710 that is less than the axial spacing 720. Similarly,the electrodes P4 and M3 may have an STS relative spacing 714 that isless than the axial spacing 716.

Returning to FIG. 2, at 208, the microcontroller 160 and/or CPU 602calculate conduction patterns based on the arrival times and/ordifference in arrival times at the LV sensing sites. For example,attention is directed to FIG. 4E. FIG. 4E illustrates an example of anLV electrode combination and a waveform propagating from the distal andto the proximal end of the LV lead. In FIG. 4E, arrows 750 represent adirection of electrical wave front propagation, where the wave frontarrives at electrode D1 at time T₁, electrode M2 at time T₂, electrodeM3 at time T₃ and electrode P4 at time T₄.

At 210, the one or more processors may identify morphologies (MPs) forcardiac signals associated with the LV activation events. The processorsanalyze the cardiac signals in connection with each LV electrode for thecorresponding LV activation events. As one simple example, theidentification of the morphologies may simply include recording thecardiac signals as a digitized signal in connection with each LVelectrode. Additionally or alternatively, the cardiac signals may beanalyzed in more detail, such as to identify peaks and valleys withinthe signal, total energy, and other characteristics of the cardiacsignals that define morphology. The morphology is saved along with atimestamp indicating a time at which the cardiac signals having themorphology were sensed. Additionally or alternatively, other informationmay be recorded with the morphology.

At 212, the one or more processors may wait a predetermined period oftime corresponding to a select time interval and then return flow to 202to repeat the operations at 202-210. The operations at 202-210 arerepeated at select intervals, such as hourly, daily, weekly and thelike, to build a CP collection and an MP collection. The CP collectionincludes a set of conduction patterns recorded over the select interval,while the MP collection includes a set of morphologies recorded over theselect interval. Next, flow may move to the operations at FIG. 3A or 3B.

FIG. 3A illustrates a process for calculating an HF trend based on theCP collection and MP collection recorded in connection with theoperations of FIG. 2 in accordance with an embodiment herein. Theoperations of FIG. 3A may be performed by one or more processors of animplantable medical device, a local external device and/or a remoteserver.

At 320, the one or more processors obtain the CP collection and the MPcollection for a time period of interest. By way of example only, theobtaining operation at 320 may include at least one of i) accessingmemory of an external device or remote server where the CP collectionand MP collection are stored, ii) receiving the CP collection and MPcollection over a wireless communications link between the IMD and alocal external device, and/or iii) receiving the CP collection and MPcollection at a remote server over a network connection. The obtainingoperation, when from the perspective of an IMD, may include sensing newconduction patterns and new morphologies in real time, and/or accessingmemory to read a stored CP collection and stored MP collection frommemory within the IMD. The obtaining operation, when from theperspective of a local external device, includes receiving the CPcollection and MP collection at a transceiver of the local externaldevice where the CP and MP collections are transmitted from an IMDand/or a remote server. The obtaining operation may be from theperspective of a remote server, such as when receiving the CP collectionand MP collection at a network interface from a local external deviceand/or directly from an IMD. The remote server may also obtain the CPand MP collection from local memory and/or from other memory, such aswithin a cloud storage environment and/or from the memory of aworkstation or clinician external programmer.

As displayed hereafter, the operations at 322 calculate a CP-based trendindicator by applying an AT metric to the CP collection, while theoperations at 328 calculate an MP-based trend indicator by applying anMP metric to the MP collection. As explained further below, the processof FIG. 3B calculates HF trend based on the CP-based and MP-based HFindicators.

At 322, the one or more processors apply one or more activation time(AT) metrics or templates to the conduction pattern collection tocalculate one or more CP trend indicators. The processors may implementspecific activation time metrics that can be used to assess the HFdisease status of a patient (i.e., improving vs. deteriorating) andpresented to the clinician. The server, local device and/or IMD can beprogrammed to send a notification message to the clinician if any ofthese metrics change (positive or negative) beyond a preset threshold,signaling the clinician if an in-clinic assessment is recommended. TheAT metric may comprise at least one of a dyssynchrony metric, conductionnonuniformity metric, conduction velocity metric, fastest conductionpathway metric or chronotropic incompetence metric. Activation timemetrics may include, but are not limited to, the following metricsdiscussed hereafter.

As one example, the activation time metric may correspond to adifference in activation times between combinations of the RV and LVsensing sites/electrodes. For example, the processors may determine thedifference in activation times between one or more combinations of RVand LV sensing sites (e.g., RV-LV D1, RV-LV M2, RV-LV M3, RV-LV P4), aswell as between one or more combinations of LV sensing sites (e.g., LVD1-LV M2, LV M2-LV M3, LV M3-LV P4). The processors determine a selectactivation time difference (also “select AT difference”) between a pairof sensing sites that satisfies a criteria of interest, such as amaximum difference in activation times. General dyssynchrony can bequantified by the maximum difference in activation times among the RVand LV electrodes, namely the pair of sensing sites for which acorresponding activation time difference is the greatest. For example,the select (e.g., maximum) activation time difference may correspond tothe LVP4 and RV sensing sites. The processors analyze the conductionpattern, associated with an individual intrinsic or paced event toidentify the activation time differences between combinations of sensingsites and to identify the maximum difference activation time associatedwith the individual intrinsic or paced event. At 322, the processorsanalyze the maximum difference activation times in connection with eachconduction pattern in the CP collection. For example, a set of 20conduction patterns in a CP collection would similarly have 20corresponding select AT differences indicative of a heart condition atthe time the corresponding conduction patterns were collected. Asexplained in connection with FIG. 3B, at 350-362, the processorsdetermine whether the CP-based trend indicator, namely select ATdifferences between the conduction patterns, increases over time,decreases over time or remains substantially constant. When the CP-basedtrend indicator (e.g., select AT difference) reduces over time acrossthe CP collection, the trend indicator is considered to be indicative ofventricular remodeling and a positive response to therapy.Alternatively, when the select AT difference increases over time acrossthe CP collection, the trend indicator is considered to be indicative ofa worsening in a HF status. Similarly, when the select differenceremains constant across the CP collection, the trend indicator isconsidered to indicate no change in a HF status.

The foregoing example is described in connection with utilizing amaximum difference in the activation times, however it is understoodthat alternative mathematical relations between the activation times maybe analyzed. For example, the processors may determine a standarddeviation over the activation times from RV to each of the four LVsensing sites across the CP collection. The standard deviation isexpected to be smaller when dyssynchrony is reduced. As explained inconnection with FIG. 3B, at 350-362, when the processors identify adecreasing trend in the standard deviation for the activation timesacross the CP collection, the trend indicator is considered to beindicative of ventricular remodeling and a positive response to therapy.Alternatively, when the processors identify an increasing trend in thestandard deviation for the activation times across the CP collection,the trend indicator is considered to be indicative of a worsening in aHF status. Similarly, when the standard deviation remains constantacross the CP collection, the trend indicator is considered to indicateno change in a HF status.

As another example, the activation time metric may correspond to aconduction non-uniformity in the LV. By way of example, conductionnon-uniformity may be determined in connection with the processdescribed in U.S. Pat. No. 9,675,805 titled “method and system forlocalizing left ventricular conduction non-uniformity”, issuing Jun. 13,2017, the complete subject matter of which is hereby expresslyincorporated by reference in its entirety. As one example, theconduction non-uniformity in the LV may be quantified by dividing i) amaximum activation time difference for each pair of neighboring LVsensing sites by ii) a total difference in activation time among all 4LV electrodes. For example, with reference to FIG. 4B, panel A, theprocessors may determine a conduction non-uniformity by determining atotal difference 464 in activation time among the four LV sensing sitesand determine the maximum AT difference for each pair of neighboring LVsensing sites (e.g., 461-463). In panel A, activation time 463 wouldcorrespond to the maximum activation time between a pair of neighboringLV sensing sites, and thus the activation time 463 would be divided bythe total difference 464 to determine a conduction non-uniformity inconnection with the conduction pattern associated with panel A. Theprocessors repeat the determination of conduction non-uniformity inconnection with each conduction panel in the CP collection.

A reduction in the conduction non-uniformity would be indicative ofventricular remodeling and a positive response to therapy. As explainedin connection with FIG. 3B, at 350-362, when the processors identify adecreasing trend in the conduction non-uniformity across the CPcollection, the trend indicator is considered to be indicative ofventricular remodeling and a positive response to therapy.Alternatively, when the processors identify an increasing trend in theconduction non-uniformity for the activation times across the CPcollection, the trend indicator is considered to be indicative of aworsening in a HF status. Similarly, when the conduction non-uniformityremains constant across the CP collection, the trend indicator isconsidered to indicate no change in a patient's HF status.

As another example, the activation time metric may correspond toconduction velocity in the LV. The processors quantify the conductionvelocity in the LV based on an assumed distance between each pairs ofneighboring LV sensing sites and the activation time difference for thepairs of neighboring LV sensing sites. The processors may calculateconduction velocity in various manners, including the process describedin U.S. Pat. No. 9,675,805, referenced above. Faster conductionvelocities would indicate ventricular remodeling and a positive responseto therapy. As explained in connection with FIG. 3B, at 350-362, whenthe processors identify an increasing decreasing trend in the conductionvelocity across the CP collection, the trend indicator is considered tobe indicative of ventricular remodeling and a positive response totherapy. Alternatively, when the processors identify a decreasing trendin the conduction velocity for the activation times across the CPcollection, the trend indicator is considered to be indicative of aworsening in a HF status. Similarly, when the conduction velocityremains constant across the CP collection, the trend indicator isconsidered to indicate no change in a patient's HF status.

Additionally or alternatively, the processors may classify the fastestconduction pathway by the order of activation of the 5 electrodes (e.g.,“RV->LVD1->LVM2->LVM3->LVP4”). A change in the order of activationindicates a change in the general direction of wave front propagation,which could be classified as either improvement or deterioration of thepatient's HF status.

As yet another example, the activation time metric may correspond tochronotropic incompetence of the LV cardiac tissue linked to a patientheart failure condition. The IMD assess chronotropic incompetence byapplying a ramped stimulation protocol. The processors assess a sequenceand time of activation during a basic cycle length at each of the LVsensing sites and record the HF assessment as a baseline or startingpoint. Thereafter, the processors assess chronotropic incompetence bydelivering a sequence of RV pacing pulses at increasing prematurity(relative to the basic cycle length). For example, the series of RVpacing pulses may be delivered 70%, 60%, 50%, 40%, etc. of the basiccycle length over time. The LV tissue should respond in a somewhatpredictable manner when the patient's heart is experiencing positiveremodeling, such as based on a priority information and/or priorbehavior by the current patient. The predictable response should occurregardless of how premature the RV pacing pulse is delivered. When theLV tissue responds in the predictable manner in response to thepremature RV pacing pulses, as explained in connection with FIG. 3B, at350-362, the one or more processors may determine that the tissue isundergoing positive remodeling and is exhibiting restored chronotropiccompetence.

At 324, the one or more processors apply a morphology metric to themorphology collection to calculate an MP trend indicator. In addition toactivation patterns, which indicate the order in which the wave frontpasses each sensing site/electrode, individual EGM morphologies can alsoreflect electromechanical changes in the ventricles. EGMs capture morecomprehensive information describing the propagating wave fronts as theymove toward and away from each electrode. It has been shown that evokedresponses sensed at LV sensing sites (in response to RV paced events)change in morphology in connection with a degradation or worsening of anHF condition or status. FIG. 4F illustrates graphs simulating EGMmorphologies for a collection of events that were recorded over timeduring HF induction in connection with rapid pacing by an IMD. EGMmorphology 490 corresponds to a baseline morphology, while EGMmorphology 491 was collected while an IMD was delivering RV rapid pacingat a rate of approximately 190 bpm. EGM morphology 492 was collectedwhile an IMD was delivering RV rapid pacing at a rate of approximately210 bpm, while EGM morphology 493 was collected while an IMD wasdelivering RV rapid pacing at a rate of approximately 230 bpm. As shownin FIG. 4F the EGM morphologies 490-493 progressively drop in amplitude(both positive and negative) and lose other details within the shapethereby indicating a progressively worsening HF status.

At 324, the one or more processors apply one or more morphology metricsto the morphology collection, such as EGM morphologies 490-493.Morphology metrics may be characterized in various manners, with eachmorphology metric used to classify the HF disease status of a patient(i.e., improving vs. deteriorating). The MP metric comprises at leastone of an electrical synchrony metric, electrically viable local tissuemetric, pacing depolarization integral metric, slope based electricalexcited ability metric or template matching score metric. Similar toactivation time metrics associated with activation times, the EGMmorphology-based metrics can be analyzed to determine HF based heartfailure indicators that exhibit HF trends. When the HF trend exceeds oneor more preset thresholds, the one or more processors may notify aclinician of a change in the trend, such as whether an HF status hasworsened, become better or otherwise.

As an example, the morphology metric may correspond to electricalsynchrony that may be determined from an EGM-based QRS duration, whichrepresents a surrogate of a standard surface ECG QRS duration. Theprocessors analyze the morphology collection and determine EGM-based QRSdurations in connection with each morphology. By way of example, the oneor more processors may implement the methods and systems described inU.S. patent application Ser. No. 16/752,839, filed 27 Jan. 2020 (nowU.S. Pat. No. 11,123,006, issued 21 Sep. 2021) titled “Method and Devicefor Electrogram Based Estimation of QRS Duration”, the complete subjectmatter of which is expressly incorporated herein by reference in itsentirety. Thus, when the processors identify a trend indicator ofinterest (350-362 in FIG. 3B) (e.g., reducing trend) in the QRS durationover the collection of morphologies, the trend indicator is consideredto be indicative of improvements an electrical resynchronization and apositive response to CRT therapy. Alternatively, when the processorsidentify an increasing trend indicator in the QRS duration over thecollection of morphologies, the trend indicator is considered to beindicative of worsening electrical synchronization and a negativeresponse to CRT therapy. Similarly, when the QRS duration remainsconstant across the morphology collection, the trend indicator isconsidered to indicate no change in a patient's HF status.

As another example, the morphology metric may correspond to whether alocal LV tissue is electrically viable. To determine a trend indicatorrelated to electrical viability of local tissue, the one or moreprocessors determine a maximum amplitude of each morphology within themorphology collection. The maximum amplitude may be a positive ornegative amplitude. The maximum amplitude quantifies an amount ofelectrical viability in myocardium in the local vicinity of thecorresponding LV sensing site. The one or more processors identify, asthe trend indicator of interest, the maximum EGM amplitude in connectionwith each morphology. When the processors identify an increasing trendor large EGM amplitude (e.g., 350-362 in FIG. 3B), the trend indicatoris considered to be indicative of an improvement in electrical viabilityof the local LV tissue and a positive response to CRT therapy.Alternatively, when the processors identify a decreasing trend orrelatively small EGM amplitude, the trend indicator is considered to beindicative of worsening electrical viability of the local LV tissue andeight negative response to CRT therapy. Similarly, when the EGMamplitude remains relatively unchanged, the trend indicator isconsidered to indicate no change in the patient's HF status.

As another example, the morphology metric may correspond to a Paceddepolarization integral (PDI). In connection there with, the one or moreprocessors may utilize a combination of the EGM QRS duration andamplitudes to apply an “area under the curve”. Trends in the size of thepaced depolarization integral represent a trend indicator of interest.When the processors identify an increasing trend in the PDI (e.g.,350-362 in FIG. 3B), the trend indicator is considered to be indicativeof an improvement in the HF status and indicates a positive response toCRT therapy. Alternatively, when the processors identify a decreasingtrend in the PDI, the trend indicator is considered to be indicative ofa worsening HF status. When the PDI remains relatively unchanged, thetrend indicator is considered to indicate no change in the patient's HFstatus.

As another example, the morphology metric may correspond to electricalexcitability which may be quantified based on morphology slope trends,such as a maximum positive upward slope or minimum downward negativeslow of the EGM morphology. The slope of the action potential for alocal LV sensing site can be used to assess electrical excitability. Thepositive or negative slope of the EGM morphology is simply thecombination of electrical activity of all of the myocytes in thevicinity of the EGM electrodes. Less viable myocardial tissue wouldyield smaller slope magnitudes. Accordingly, when the processorsidentify increasing trends in the slope magnitude (e.g., 350-362 in FIG.3B), the trend indicator is considered to be indicative of animprovement in the electrical excitability of the myocardium.Alternatively, when the processors identify decreasing trends in theslope magnitude, the trend indicator is considered to be indicative ofworsening in the electrical excitability of the myocardium. When theslope magnitude remains relatively unchanged over a morphologycollection, the trend indicator is considered to indicate no change inthe patient's HF status.

As another example, the morphology metric may correspond to a templatematching score. The EGM morphology tends to return toward a standardshape, and away from an LBBB-type morphology, as the heart respondsfavorably to CRT therapy. The one or more processors may compare themorphologies within the morphology collection to one or more morphologytemplates, and determine one or more scores concerning a degree to whichthe individual morphologies match a morphology template. The morphologytemplates may represent known, normal EGM morphologies. Changes in thescore represent a trend in a score indicator that affords a desirablefeature to assess HF status. For example, a known, normal EGM morphologytemplate could be obtained, and the one or more processors apply across-correlation coefficient (CC) of patient's LV EGM morphology to theknown, normal EGM morphology template. Positive trending in the crosscorrelation would indicate patients responding favorably to CRT. Thus,when the processors identify positive trends in the cross correlation(e.g., 350-362 in FIG. 3B), the trend indicator is considered to beindicative of an improvement in the patient's HF status. Alternatively,when the processors identify negative trends of the cross correlation,the trend indicator is considered to be indicative of a worsening in thepatient's HF status. When the cross correlation trend remains relativelyunchanged, the trend indicator is considered to indicate no change inthe patient's HF status.

At 326, the one or more processors determine whether to repeat theapplication of the morphology metric in connection with inter-electrodedifferences between morphologies associated with different LV sensingsites. If so, flow returns to 324 and the morphology metric is appliedto inter-electrode differences between the morphologies to calculate andinter-electrode MP trend indicator. For example, the microcontroller 160and/or CPU 602 may identify adjacent electrode combinations available atthe LV lead 124. For example, when the LV lead 124 includes theelectrodes D1, M2, M3 and P4, the adjacent electrode combinations wouldinclude D1+M2, M2+M3 and M3+P4. As noted herein, an adjacent electrodecombination may include more than two electrodes that are arrangedsuccessive with one another. For example, an adjacent electrodecombination may represent D1+M2+M3, M2+M3+P4, and the like. Eachadjacent electrode combination represents adjacent LV sensing sites forwhich the process may determine whether the local tissue exhibitsheterogeneity electrical behavior or dyssynchrony.

The process described above in connection with FIG. 3A appliesactivation time metrics and morphology metrics to morphologies andconduction patterns measured at individual LV sensing sites/LVelectrode. Additionally or alternatively, the AT metric and morphologymetrics may be applied to ensembles (e.g., mean, average or otherstatistical combinations) of morphologies and conduction patterns fromsome or all RV and LV electrodes. The foregoing AT and morphologymetrics are expected to calculate CP based and MP based trend indicatorsthat change as the ventricles respond to CRT. It is also possible thatdifferences in the EGM morphology metrics between neighboring electrodesmay slowly diminish as wave fronts propagate across the LV sensing sitesmore evenly. Therefore, the processors may apply the morphology metrics(based on the decision at 326) to inter-electrode differences inconnection with assessing HF progression and tracking theinter-electrode differences over time.

When the processors determine to not repeat the morphology metric inconnection with inter-electrode differences (or the morphology metrichas already been applied to inter-electrode differences), flow continuesto 328.

At 328, the one or more processors store the CP trend indicators and MPtrend indicators along with timestamps indicating the point in time ortime interval for which the HF indicators correspond. Thereafter, flowcontinues to FIG. 3B, as explained herein, the CP based and MP basedtrend indicators are used to calculate HF trends and such trends areused to classify an HF status (also referred to as a patient condition).

FIG. 3B illustrates a process for classifying a patient condition basedon trend indicators to form an HF assessment and to providenotifications of the HF assessment in accordance with embodimentsherein. The operations of FIG. 3B may be performed by one or moreprocessors of an implantable medical device, a local external deviceand/or a remote server. By way of example, the process of FIG. 3B mayrepresent a device-based method to establish long-term trends inventricular reverse remodeling as patients respond to CRT over time,independent of occasional in-clinic echocardiography or ECGmeasurements. Daily averages of LV electrode activation patterns and/orEGM morphologies (e.g., EGM waveforms, EGM duration, QRS duration) canbe saved and transmitted to a remote server. Clinicians may accessrecords on the server and/or the server may push notifications toclinicians to enable clinicians to view long-term trends as theydevelop.

Embodiments herein provide more than simply displaying combinations ofthe aforementioned metrics, as the mere display of raw data provideslimited treatment information to clinicians. Instead, embodiments hereinprovide a method and system in which (1) the IMD collects activationtimes and EGMs at discrete intervals (e.g., hourly, daily, weekly), (2)the IMD transmits the data to a local external device and/or remoteserver, (3) the IMD, local external device and/or remote server applythe morphology and AT metrics, (4) the IMD, local external device and/orremote server classify the patient's current response to HF therapy(e.g., improved, deteriorated, no change), and (5) the IMD, localexternal device and/or remote server notify the clinician (if theclinician desires to receive a notification) if a patient's HF statuschanges. Embodiments herein enable programmable thresholds to be set inconnection with classifying a patient's HF response/status. For example,if the EGM QRS duration is elevated by more than 5% (relative tobaseline) for 7 consecutive days, an email can be sent to the clinicianwith a summary of the QRS duration history and a recommendation for anin-clinic follow-up assessment. Various HF trending parameters extractedfrom RV-LV conduction delays and EGM morphologies can be also combinedas one HF index or a composite score based on X out of Y parameterscrossing respective thresholds. Accordingly, the physician is providedwith one single index that describes the overall HF status based onconduction and morphology. Additionally or alternatively, physicians canchoose boundaries for alerts based on their standard of practice.

The description above describes the monitoring of activation patternsand EGM morphologies during intrinsic conduction (either A-paced orA-sensed with intrinsic conduction to the RV and LV electrodes).However, the activation patterns and EGM morphologies can also betracked in parallel for other stimulus origins, including RV-paced andLV-paced at each of the 4 electrodes.

At 350, the one or more processors obtain and compare one or more CPbased trend indicators with one or more thresholds. At 352, the one ormore processors obtain and compare one or more MP based trend indicatorswith one or more thresholds. At 354, the one or more processorsdetermine whether the CP and MP trend indicators satisfy positivethresholds. When the trend indicators satisfy one or more positivethresholds, flow moves to 356. When the trend indicators do not satisfypositive thresholds, flow moves to 358. At 358, the one or moreprocessors determine whether the CP and MP trend indicators satisfynegative thresholds. When the trend indicators satisfy negativethresholds, flow moves to 360. When the trend indicators do not satisfynegative thresholds, flow moves to 362.

Returning to 354, when flow advances to 356, at 356 the one or moreprocessors classify the patient condition as “improving” for an HFassessment. Alternatively, when flow progresses to 360, the one or moreprocessors classify the patient condition as “worsening” for the HFassessment. When the trend indicators do not indicate either of animproving or worsening HF assessment, flow moves from 354 to 358 to 362.At 362, the one or more processors classify the patient condition as “nochange” for the HF assessment.

Next, the operations at 350-362 are described in connection with one ormore particular trend indicators. As noted above in connection with FIG.3B, the CP-based trend indicator may be in connection with at least oneof a dyssynchrony metric, conduction nonuniformity metric, conductionvelocity metric, fastest conduction pathway metric or chronotropicincompetence metric, with one or more thresholds. The MP-based trendindicator may be in connection with at least one of an electricalsynchrony metric, electrically viable local tissue metric, pacingdepolarization integral metric, slope based electrical excited abilitymetric or template matching score metric. The thresholds may be positiveor negative in that, when the trend indicator satisfies a positivethreshold, the HF assessment is set to positive (e.g., the patient'scondition is improving). Alternatively, when the trend indicatorsatisfies a negative threshold, the HF assessment is set to negative(e.g., the patient's condition is worsening). When the trend indicatordoes not satisfy the threshold, the HF assessment is set to “no change”.

By way of example only, when the AT metric corresponds to generaldyssynchrony, a positive threshold may be set at 354 such that when amaximum difference in activation times among the sensing sites fallsbelow a difference threshold, the positive threshold would be determinedto be satisfied and flow would move to 356, depending upon other metricsconsidered. At 356, the patient condition would be classified asimproving. Additionally or alternatively, when the AT metric correspondsto conduction velocity, a positive threshold may be set at 354 such thatwhen the conduction velocity exceeds a velocity threshold, the positivethreshold would be determined to be satisfied and flow would move to356. As MP metric based examples, when the MP based metric correspondsto electrical synchrony, a QRS duration threshold may be defined. At354, when the MP trend indicator for the QRS duration falls below theQRS duration threshold, this would be interpreted as satisfying apositive threshold at 354 and flow would advanced the 356, dependingupon other metrics considered.

Alternatively, at 354, when a maximum difference in activation timesexceeds the difference threshold, the positive threshold would not besatisfied and flow would move to 358. At 358, the maximum difference inactivation times is compared to a negative threshold (e.g., a negativedifference threshold that is higher than the positive differencethreshold). When the maximum difference exceeds the higher negativedifference threshold, the negative threshold would be satisfied and flowwould move to 360 where the HF assessment is set to indicate that thepatient condition is worsening. Alternatively, when the maximumdifference falls between the lower positive threshold and highernegative threshold, flow would navigate to 362 where the HF assessmentwould be set to a no change assessment.

It is recognized that one or more combinations of the CP-based trendindicators and MP-based trend indicators may be compared tocorresponding positive and negative thresholds at 354 and 358 todetermine the HF assessment. Additionally or alternatively, theoperations at 354 and 358 may apply a weighted combinations of thecomparisons of the trend indicators to positive and negative thresholds.For example, when an individual CP-based trend indicator is compared toa corresponding positive threshold, a score may be applied indicative ofhow close the trend indicator is to a threshold. The comparisons andscores may be combined for multiple trend indicators. When thecumulative comparison is sufficient, flow may advance to 356.Alternatively, when the multiple trend indicators do not score highenough, flow moves to 358. At 358, trend indicators for multiple CP andMP-based trends may be combined in a similar manner. Additionally oralternatively, the operations at 354 through 358 may be combined into asingle threshold comparison.

Following the classification of patient condition as a correspondingtype of HF assessment, flow moves to 364. At 364, the one or moreprocessors determine whether an HF assessment notification should beconveyed to one or more individuals. When the processors determined tonot send an HF assessment notification, the process of FIG. 3B ends.Alternatively, when the processors determined to send an HF assessmentnotification, flow continues to 364.

At 366, the one or more processors prepare an HF assessmentnotification. For example, the HF assessment notification may includethe CP trend trends, the MP trend trends, the classification of thepatient condition, as well as other information in connection therewith. The HF assessment notification is conveyed to one or moredesignated destination devices. For example, the HF assessmentnotification may be sent to an electronic account (e.g., email, SMStext) of a physician caring for an individual. The HF assessmentnotification may be sent to a central clearinghouse where a group ofindividuals monitor and further process the HF assessment notifications.Additionally or alternatively, the HF assessment notification may besent to one or more devices within a medical network (e.g.,workstations, smart phones, tablet devices, laptop computers and thelike) for one or more physicians caring for an individual.

FIG. 5 illustrates a simplified block diagram of internal components ofthe IMD 100 (e.g., IMD) according to an embodiment. While a particularIMD 100 is shown, it is for illustration purposes only. One of skill inthe art could readily duplicate, eliminate, or disable the appropriatecircuitry in any desired combination to provide a device capable oftreating the appropriate chamber(s) with cardioversion, defibrillation,and pacing stimulation. The housing/CAN 140 for IMD 100 may beprogrammably selected to act as the anode for at least some unipolarmodes. The CAN 140 may further be used as a return electrode alone or incombination with one or more of the coil electrodes 128, 136, and 138(all shown in FIG. 1) for shocking purposes.

The IMD 100 further includes a connector (not shown) having a pluralityof terminals, 142, 143, 144 ₁-144 ₄, 146, 148, 152, 154, 156, and 158(shown schematically and, for convenience, with the names of theelectrodes to which they are connected). As such, to achieve rightatrial (RA) sensing and pacing, the connector includes at least an RAtip terminal (A_(R) TIP) 142 adapted for connection to the atrial tipelectrode 122 (shown in FIG. 1) and an RA ring (A_(R) RING) electrode143 adapted for connection to the RA ring electrode 123 (shown in FIG.1). To achieve left chamber sensing, pacing, and shocking, the connectorincludes an LV tip terminal 144 ₁ adapted for connection to the D1electrode and additional LV electrode terminals 144 ₂, 144 ₃, and 144 ₄adapted for connection to the M2, M3, and P4 electrodes, respectively,of the quadripolar LV lead 124 (shown in FIG. 1). The connector alsoincludes an LA ring terminal (A_(L) RING) 146 and an LA shockingterminal (A_(L) COIL) 148, which are adapted for connection to the LAring electrode 127 (shown in FIG. 1) and the LA coil electrode 128(shown in FIG. 1), respectively. To support right chamber sensing,pacing, and shocking, the connector further includes an RV tip terminal(V_(R) TIP) 152, an RV ring terminal (V_(R) RING) 154, an RV coilterminal (RV COIL) 156, and an SVC coil terminal (SVC COIL) 158, whichare adapted for connection to the RV tip electrode 132, the RV ringelectrode 134, the RV coil electrode 136, and the SVC coil electrode 138(all four electrodes shown in FIG. 1), respectively.

The IMD 100 includes a programmable microcontroller 160 (also referredto herein as a control unit or controller) that includes amicroprocessor or equivalent control circuitry, designed specificallyfor controlling the delivery of stimulation therapy. The microcontroller160 may further include RAM or ROM memory, logic and timing circuitry,state machine circuitry, and/or I/O circuitry. The microcontroller 160includes the ability to process or monitor input signals (data) ascontrolled by a program code stored in a designated block of memory. Thedetails of the design and operation of the microcontroller 160 are notcritical to the invention. Rather, any suitable microcontroller 160 maybe used that carries out the functions described herein. Among otherthings, the microcontroller 160 receives, processes, and manages storageof digitized cardiac data sets from the various sensors and electrodes.

A pulse generator 170 and a pulse generator 172 are configured togenerate and deliver a pacing pulse from at least one RV or RA pacingsite, such as at one or more pacing sites along the RA lead 120, the RVlead 130, and/or the LV lead 124 (all three leads shown in FIG. 1). Thepulse generators 170, 172 are controlled by the microcontroller 160 viaappropriate control signals to trigger or inhibit the stimulationpulses, including the timing and output of the pulses. The electrodeconfiguration switch 174 may include a plurality of switches forconnecting the desired electrodes to the appropriate I/O circuits,thereby providing complete electrode programmability. Accordingly, theswitch 174, in response to a control signal 180 from the microcontroller160, controls the polarity of the stimulation pulses (e.g., unipolar,bipolar, combipolar, etc.) by selectively actuating the appropriatecombination of switches (not shown) as is known in the art. The switch174 also switches among the various LV electrodes 126 to select thechannels (e.g., vectors) to deliver and/or sense one or more of thepacing pulses. As explained herein, the switch 174 couples multiple LVelectrode terminals 144 ₁-144 ₄ correspond to cathodes when connected tothe pulse generator 172.

Atrial sensors or sensing circuits 182 and ventricular sensors orsensing circuits 184 may also be selectively coupled to the RA lead 120,the LV lead 124, and/or the RV lead 130 (all three leads shown inFIG. 1) through the switch 174. The atrial and ventricular sensors 182and 184 have the ability to detect the presence of cardiac activity ineach of the four chambers of the heart 105 (shown in FIG. 1). Forexample, the ventricular sensor 184 is configured to sense LV activationevents at multiple LV sensing sites, where the activation events aregenerated in response to a pacing pulse or an intrinsic event. In anembodiment, the ventricular sensor 184 senses along at least foursensing vectors, each sensing vector utilizing a sensing electrode inthe left ventricle.

The atrial sensing circuits 182 and ventricular sensing circuits 184 mayinclude dedicated sense amplifiers, multiplexed amplifiers, or sharedamplifiers. The switch 174 determines the “sensing polarity” or sensingvector of the cardiac signal by selectively opening and/or closing theappropriate switches, as is known in the art. In this way, a clinicianmay program the sensing polarity independent of the stimulationpolarity.

Cardiac signals are also applied to the inputs of an analog-to-digital(ND) data acquisition system 190. The A/D data acquisition system 190 isconfigured to acquire intracardiac electrogram (EGM) signals, convertthe raw analog data into a digital signal, and store the digital signalsfor later processing and/or telemetric transmission. The telemetrictransmission may be to an external programmer device 104, a bedsidemonitor, and/or a personal advisory module (PAM) 102. The dataacquisition system 190 may be operatively coupled to the RA lead 120,the LV lead 124, and the RV lead 130 (all three leads shown in FIG. 1)through the switch 174 to sample cardiac signals across any pair ofdesired electrodes.

The microcontroller 160 includes timing control module 161 to controlthe timing of the stimulation pacing pulses, including, but not limitedto, pacing rate, atrio-ventricular delay, interatrial conduction delay,interventricular conduction delay, and/or intraventricular delay. Thetiming control module 161 can also keep track of the timing ofrefractory periods, blanking intervals, noise detection windows, evokedresponse detection windows, alert intervals, marker channel timing,etc., which is known in the art.

The microcontroller 160 further includes an arrhythmia detector 162 foroperating the system 100 as an implantable cardioverter/defibrillatordevice. The detector 162 determines desirable times to administervarious therapies. For example, the detector 162 may detect theoccurrence of an arrhythmia and automatically control the application ofan appropriate electrical shock therapy to the heart aimed atterminating the detected arrhythmia.

The microcontroller 160 includes a therapy controller 165 to managepacing therapy, which can be performed in conjunction with CRT pacing.As an example, the therapy controller 165 may control the pulsegenerator 172 to simultaneously deliver a pacing pulse over a selectpacing vector. The arrhythmia detector 162, morphology detector 164,and/or therapy controller 165 may be implemented in hardware as part ofthe microcontroller 160, or as software/firmware instructions programmedinto the system and executed on the microcontroller 160 during certainmodes of operation. The therapy controller 165 also controls delivery ofCRT pacing pulses to synchronize the contractions of the right and leftventricles. The therapy controller 165 controls the number, timing, andoutput of the CRT pacing pulses delivered during each cardiac cycle, aswell as over which pacing vectors the pacing pulses are to be delivered.

The microcontroller 160 may additionally include a morphology detector164, a conduction pattern detector 163, and a trend analysis module 168that perform the operations described herein in connection with FIGS.1-4F. The morphology detector 164 determines morphologies for cardiacsignals sensed at the LV activation sites and associated with LVactivation events. The conduction pattern detector 163 determinesconduction patterns across the LV sensing sites based on LV activationevents. The trend analysis module 168 may implement the operationsdescribed in connection with FIGS. 3A and 3B, such as to calculate an HFtrend based on the CP collection and the MP collection and classifies apatient condition based on the HF trend to form an HF assessment. Amongother things, the trend analysis module 168 calculates a CP-based trendindicator by applying an AT metric to the CP collection; and calculatesan MP-based trend indicator by applying an MP metric to the MPcollection. The trend analysis module 168 applying, as the AT metric, atleast one of a dyssynchrony metric, conduction nonuniformity metric,conduction velocity metric, fastest conduction pathway metric orchronotropic incompetence metric. The trend analysis module 168 applies,as the MP metric, at least one of an electrical synchrony metric,electrically viable local tissue metric, pacing depolarization integralmetric, slope based electrical excited ability metric or templatematching score metric.

The microcontroller 160 is further coupled to a memory 194 by a suitabledata/address bus 196. The programmable operating parameters used by themicrocontroller 160 are stored in the memory 194 and modified, asrequired, in order to customize the operation of IMD 100 to suit theneeds of a particular patient. Such operating parameters define, forexample, the amplitude or magnitude of the generated pacing pulses, waveshape, pulse duration, and/or vector (e.g., including electrodepolarity) for the pacing pulses. Other pacing parameters may includebase rate, rest rate, and/or circadian base rate. The memory 194 alsostores conduction patterns or morphologies, CP collections, MPcollections, CP-based trend indicators, MP-based trend indicators, HFtrends, AT metrics, MP metrics as well as other data and informationdescribed herein.

Optionally, the operating parameters of the implantable IMD 100 may benon-invasively programmed into the memory 194 through a telemetrycircuit 101 in telemetric communication with an external programmerdevice 104 or a bedside monitor 102, such as a programmer,trans-telephonic transceiver, or a diagnostic system analyzer. Thetelemetry circuit 101 is activated by the microcontroller 160 through acontrol signal 106. The telemetry circuit 101 may allow IEGMs,conduction patterns, morphologies, CP collections, MP collections,CP-based trend indicators, MP-based trend indicators, HF trends, ATmetrics, MP metrics as well as other data and information describedherein, and status information relating to the operation of IMD 100(contained in the microcontroller 160 or the memory 194) to be sent tothe external programmer device 104 and/or bedside monitor 102, andvice-versa, through an established communication link 103. An internalwarning device 121 may be provided for generating perceptible warningsignals to a patient and/or caregiver via vibration, voltage, or othermethods.

IMD 100 further includes an accelerometer or other physiologic sensor108. The physiologic sensor 108 is commonly referred to as a“rate-responsive” sensor because it may be used to adjust the pacingstimulation rate according to the exercise state (e.g., heart rate) ofthe patient. However, the physiological sensor 108 may further be usedto detect changes in cardiac output, changes in the physiologicalcondition of the heart, and/or diurnal changes in activity (e.g.,detecting sleep and wake states and arousal from sleep).

The IMD 100 additionally includes a battery 110, which providesoperating power to all of the circuits therein. The makeup of thebattery 110 may vary depending on the capabilities of IMD 100. If thesystem only provides low voltage therapy (e.g., for repetitive pacingpulses), a lithium iodine or lithium copper fluoride cell may beutilized. For a IMD that employs shocking therapy, the battery may beconfigured to be capable of operating at low current drains for longperiods and then providing high-current pulses (for capacitor charging)when the patient requires a shock pulse. The battery 110 may also beconfigured to have a predictable discharge characteristic so thatelective replacement time can be detected.

Optionally, the IMD 100 includes an impedance measuring circuit 112,which is enabled by the microcontroller 160 via a control signal 115.Uses for an impedance measuring circuit 112 include, but are not limitedto, lead impedance surveillance during the acute and chronic phases forproper lead positioning or dislodgement; detecting operable electrodesand automatically switching to an operable pair if dislodgement occurs;measuring respiration or minute ventilation; measuring thoracicimpedance for determining shock thresholds; detecting when the devicehas been implanted; measuring respiration; and detecting the opening ofheart valves, etc. The impedance measuring circuit 112 is coupled to theswitch 174 so that any desired electrode may be used.

The above described implantable medical device 100 was described as anexemplary IMD. One of ordinary skill in the art would understand thatone or more embodiments herein may be used with alternative types ofimplantable devices. Accordingly, embodiments should not be limited tousing only the above described device 100.

FIG. 6 illustrates a functional block diagram of an external device 600that is operated in accordance with the processes described herein andto interface with the implantable medical device 100 as shown in FIGS. 1and 2 and described herein. The external device 600 may be a localexternal device, an external programmer device and the like. Theexternal device 600 may take the form of a workstation, a portablecomputer, an IMD programmer, a tablet device, a laptop computer, a smartphone, a PDA, and the like. The external device 600 includes an internalbus that connects/interfaces with a Central Processing Unit (CPU) 602,ROM 604, RAM 606, a hard drive 608, a speaker 610, a printer 612, aCD-ROM drive 614, a floppy drive 616, a parallel I/O circuit 618, aserial I/O circuit 620, a display 622, a touch screen 624, a standardkeyboard 626, custom keys 628, and/or a telemetry subsystem 630. Theinternal bus is an address/data bus that transfers information betweenthe various components described herein. The hard drive 608 may storeoperational programs as well as data, such as waveform templates,determinations on presence of PNS at various electrode locations, and/orcapture thresholds for pacing vectors.

The CPU 602 includes a microprocessor, a micro-controller, and/orequivalent control circuitry, designed specifically to controlinterfacing with the external device 600 and with the IMD 100. The CPU602 may include RAM or ROM memory, logic and timing circuitry, statemachine circuitry, and/or I/O circuitry to interface with the IMD 100.The ROM 604, RAM 606 and/or hard drive 608 store program instructionsthat one executed by one or more processors (e.g., the CPU 602) toperform all or a portion of the operations described herein inconnection with FIGS. 3A-3B.

The display 622 may be connected to a video display 632. The display 622displays various forms of information related to the processes describedherein. The touch screen 624 may display graphic user informationrelating to the IMD 100. The touch screen 624 accepts a user's touchinput 634 when selections are made. The keyboard 626 (e.g., a typewriterkeyboard 636) allows a user to enter data to displayed fields, as wellas interface with the telemetry subsystem 630. Furthermore, custom keys628 turn on/off 638 (e.g., EVVI) the external device 600. The printer612 prints copies of reports 640 for a physician to review or to beplaced in a patient file, and speaker 610 provides an audible warning(e.g., sounds and tones 642) to the user. The parallel I/O circuit 618interfaces with a parallel port 644. The serial I/O circuit 620interfaces with a serial port 646. The floppy drive 616 acceptsdiskettes 648. Optionally, the floppy drive 616 may include a USB portor other interface capable of communicating with a USB device such as aflash memory stick. The CD-ROM drive 614 accepts CD ROMs 650. The CD-ROMdrive 614 optionally may include a DVD port capable of reading and/orwriting DVDs. Optionally one or more of the peripheralcircuits/components at 610-620 may be omitted.

The telemetry subsystem 630 includes a central processing unit (CPU) 652in electrical communication with a telemetry circuit 654, whichcommunicates with both an IEGM circuit 656 and a network interface 658.The IEGM circuit 656 may be connected to leads 660. The IEGM circuit 656is also connected to the implantable leads 120, 124 and 130 (shown inFIG. 1) to receive and process IEGM cardiac signals. Optionally, theIEGM cardiac signals sensed by the leads 120, 124 and 130 may becollected by the IMD 100 and then wirelessly transmitted to thetelemetry subsystem 630 input of the external device 600. Optionally,the IEGM circuit 656 AB omitted entirely, such as in smart phones andstandard commercially available laptop computers, tablet devices and thelike.

The telemetry circuit 654 is configured to wirelessly communicate withthe IMD 100. The network interface 658 is configured to communicate overa wired or wireless network, such as with a remote server. The externaldevice 600 may wirelessly communicate with the IMD 100 and utilizeprotocols, such as Bluetooth, GSM, infrared wireless LANs, HIPERLAN, 3G,4G, satellite, as well as circuit and packet data protocols, and thelike. Alternatively, a hard-wired connection may be used to connect theexternal device 600 to the IMD 100.

FIG. 7 illustrates a system 730 in accordance with embodiments herein.The system 730 includes a server 732 connected to a database 734, IMDs733, a programmer 736, a local monitoring device 738 and a userworkstation 740 electrically connected to a network 742. Any of theprocessor-based components in FIG. 7 (e.g., workstation 740, IMD 733,cell phone 744, local monitoring device 746, server 732, programmer 736)may perform the processes discussed herein. For example, the IMD 733 mayperform the collection of conduction patterns and morphologies. The IMD733, cell phone 744, local monitoring device 746, programmer 736,workstation 740 and/or server 732 may perform the calculation of theCP-based and MP-based trend indicators and/or the classification of thepatent condition and transmission of the notification of the HFassessment.

The network 742 may provide cloud-based services over the internet, avoice over IP (VoIP) gateway, a local plain old telephone service(POTS), a public switched telephone network (PSTN), a cellular phonebased network, and the like. Alternatively, the communication system 742may be a local area network (LAN), a medical campus area network (CAN),a metropolitan area network (MAN), or a wide area network (WAM). Thecommunication system 742 serves to provide a network that facilitatesthe transfer/receipt of data and other information between local andremote devices (relative to a patient). The server 732 is a computersystem that provides services to the other computing devices on thenetwork 742. The server 732 controls the communication of informationsuch as conduction patterns or morphologies, CP collections, MPcollections, CP-based trend indicators, MP-based trend indicators, HFtrends, AT metrics, MP metrics as well as other data and informationdescribed herein, as well as cardiac activity data, bradycardia episodeinformation, asystole episode information, AF episode information,markers, cardiac signal waveforms, ventricular and atrial heart rates,and detection thresholds. The server 732 interfaces with the network 742to transfer information (e.g., conduction patterns or morphologies, CPcollections, MP collections, CP-based trend indicators, MP-based trendindicators, HF trends, AT metrics, MP metrics as well as other data andinformation described herein) between the programmer 736, localmonitoring devices 738, 746, user workstation 740, cell phone 744 anddatabase 734. The database 734 stores information such as conductionpatterns or morphologies, CP collections, MP collections, CP-based trendindicators, MP-based trend indicators, HF trends, AT metrics, MP metricsas well as other data and information described herein, as well ascardiac activity data, AF episode information, AF statistics,diagnostics, markers, cardiac signal waveforms, ventricular and atrialheart rates, detection thresholds, and the like, for a patientpopulation. The information is downloaded into the database 734 via theserver 732 or, alternatively, the information is uploaded to the server732 from the database 734. The programmer 736 may reside in a patient'shome, a hospital, or a physician's office. The programmer 736 interfaceswith (e.g., in connection with a pacemaker) the IMD 733. The programmer736 may wirelessly communicate with the IMD 733 and utilize protocols,such as Bluetooth, GSM, infrared wireless LANs, HIPERLAN, 3G, satellite,as well as circuit and packet data protocols, and the like.Alternatively, a telemetry “wand” connection may be used to connect theprogrammer 736 to the IMD 733. The programmer 736 is able to acquire ECGfrom surface electrodes on a person (e.g., ECGs), electrograms (e.g.,EGM) signals from the IMD 733, and/or cardiac activity data, AF episodeinformation, AF statistics, diagnostics, markers, cardiac signalwaveforms, ventricular and atrial heart rates, sensing parametersettings and detection thresholds from the IMD 733. The programmer 736interfaces with the network 742, either via the internet, to upload theinformation acquired from the surface ECG unit 720, or the IMD 733, tothe server 732.

The local monitoring device 738 interfaces with the communication system742 to upload to the server 732 one or more of conduction patterns ormorphologies, CP collections, MP collections, CP-based trend indicators,MP-based trend indicators, HF trends, AT metrics, MP metrics as well asother data and information described herein, as well as cardiac activitydata set, AF episode information, AF statistics, diagnostics, markers,cardiac signal waveforms, ventricular and atrial heart rates, sensingparameter settings and detection thresholds. In one embodiment, thesurface ECG unit 720 and the IMD 733 have a bi-directional connectionwith the local RF monitoring device 738 via a wireless connection. Thelocal monitoring device 738 is able to acquire conduction patterns ormorphologies, CP collections, MP collections, CP-based trend indicators,MP-based trend indicators, HF trends, AT metrics, MP metrics as well asother data and information described herein, from the IMD 733, and/orcardiac signal waveforms, ventricular and atrial heart rates, anddetection thresholds from the IMD 733.

The user workstation 740 may be utilized by a physician or medicalpersonnel to interface with the network 742 to download conductionpatterns or morphologies, CP collections, MP collections, CP-based trendindicators, MP-based trend indicators, HF trends, AT metrics, MP metricsas well as other data and information described herein from the database734, from the local monitoring devices 738, 746, from the IMD 733 orotherwise. Once downloaded, the user workstation 740 may process thedata in accordance with one or more of the operations described above.The user workstation 740 may upload/push settings (e.g., sensingparameter settings), IMD instructions, other information andnotifications to the cell phone 744, local monitoring devices 738,programmer 736, server 732 and/or IMD 733. For example, the userworkstation 740 may provide instructions to the IMD 733 in order toupdate sensing parameter settings when the IMD 733 declares too manyfalse AF detections.

CLOSING STATEMENTS

It should be clearly understood that the various arrangements andprocesses broadly described and illustrated with respect to the Figures,and/or one or more individual components or elements of sucharrangements and/or one or more process operations associated of suchprocesses, can be employed independently from or together with one ormore other components, elements and/or process operations described andillustrated herein. Accordingly, while various arrangements andprocesses are broadly contemplated, described and illustrated herein, itshould be understood that they are provided merely in illustrative andnon-restrictive fashion, and furthermore can be regarded as mereexamples of possible working environments in which one or morearrangements or processes may function or operate.

As will be appreciated by one skilled in the art, various aspects may beembodied as a system, method or computer (device) program product.Accordingly, aspects may take the form of an entirely hardwareembodiment or an embodiment including hardware and software that may allgenerally be referred to herein as a “circuit,” “module” or “system.”Furthermore, aspects may take the form of a computer (device) programproduct embodied in one or more computer (device) readable storagemedium(s) having computer (device) readable program code embodiedthereon.

Any combination of one or more non-signal computer (device) readablemedium(s) may be utilized. The non-signal medium may be a storagemedium. A storage medium may be, for example, an electronic, magnetic,optical, electromagnetic, infrared, or semiconductor system, apparatus,or device, or any suitable combination of the foregoing. More specificexamples of a storage medium would include the following: a portablecomputer diskette, a hard disk, a random access memory (RAM), a dynamicrandom access memory (DRAM), a read-only memory (ROM), an erasableprogrammable read-only memory (EPROM or Flash memory), a portablecompact disc read-only memory (CD-ROM), an optical storage device, amagnetic storage device, or any suitable combination of the foregoing.

Program code for carrying out operations may be written in anycombination of one or more programming languages. The program code mayexecute entirely on a single device, partly on a single device, as astand-alone software package, partly on single device and partly onanother device, or entirely on the other device. In some cases, thedevices may be connected through any type of network, including a localarea network (LAN) or a wide area network (WAN), or the connection maybe made through other devices (for example, through the Internet usingan Internet Service Provider) or through a hard wire connection, such asover a USB connection. For example, a server having a first processor, anetwork interface, and a storage device for storing code may store theprogram code for carrying out the operations and provide this codethrough its network interface via a network to a second device having asecond processor for execution of the code on the second device.

Aspects are described herein with reference to the Figures, whichillustrate example methods, devices and program products according tovarious example embodiments. These program instructions may be providedto a processor of a general purpose computer, special purpose computer,or other programmable data processing device or information handlingdevice to produce a machine, such that the instructions, which executevia a processor of the device implement the functions/acts specified.The program instructions may also be stored in a device readable mediumthat can direct a device to function in a particular manner, such thatthe instructions stored in the device readable medium produce an articleof manufacture including instructions which implement the function/actspecified. The program instructions may also be loaded onto a device tocause a series of operational steps to be performed on the device toproduce a device implemented process such that the instructions whichexecute on the device provide processes for implementing thefunctions/acts specified.

The units/modules/applications herein may include any processor-based ormicroprocessor-based system including systems using microcontrollers,reduced instruction set computers (RISC), application specificintegrated circuits (ASICs), field-programmable gate arrays (FPGAs),logic circuits, and any other circuit or processor capable of executingthe functions described herein. Additionally or alternatively, themodules/controllers herein may represent circuit modules that may beimplemented as hardware with associated instructions (for example,software stored on a tangible and non-transitory computer readablestorage medium, such as a computer hard drive, ROM, RAM, or the like)that perform the operations described herein. The above examples areexemplary only, and are thus not intended to limit in any way thedefinition and/or meaning of the term “controller.” Theunits/modules/applications herein may execute a set of instructions thatare stored in one or more storage elements, in order to process data.The storage elements may also store data or other information as desiredor needed. The storage element may be in the form of an informationsource or a physical memory element within the modules/controllersherein. The set of instructions may include various commands thatinstruct the modules/applications herein to perform specific operationssuch as the methods and processes of the various embodiments of thesubject matter described herein. The set of instructions may be in theform of a software program. The software may be in various forms such assystem software or application software. Further, the software may be inthe form of a collection of separate programs or modules, a programmodule within a larger program or a portion of a program module. Thesoftware also may include modular programming in the form ofobject-oriented programming. The processing of input data by theprocessing machine may be in response to user commands, or in responseto results of previous processing, or in response to a request made byanother processing machine.

It is to be understood that the subject matter described herein is notlimited in its application to the details of construction and thearrangement of components set forth in the description herein orillustrated in the drawings hereof. The subject matter described hereinis capable of other embodiments and of being practiced or of beingcarried out in various ways. Also, it is to be understood that thephraseology and terminology used herein is for the purpose ofdescription and should not be regarded as limiting. The use of“including,” “comprising,” or “having” and variations thereof herein ismeant to encompass the items listed thereafter and equivalents thereofas well as additional items.

It is to be understood that the above description is intended to beillustrative, and not restrictive. For example, the above-describedembodiments (and/or aspects thereof) may be used in combination witheach other. In addition, many modifications may be made to adapt aparticular situation or material to the teachings herein withoutdeparting from its scope. While the dimensions, types of materials andcoatings described herein are intended to define various parameters,they are by no means limiting and are illustrative in nature. Many otherembodiments will be apparent to those of skill in the art upon reviewingthe above description. The scope of the embodiments should, therefore,be determined with reference to the appended claims, along with the fullscope of equivalents to which such claims are entitled. In the appendedclaims, the terms “including” and “in which” are used as theplain-English equivalents of the respective terms “comprising” and“wherein.” Moreover, in the following claims, the terms “first,”“second,” and “third,” etc. are used merely as labels, and are notintended to impose numerical requirements on their objects or order ofexecution on their acts.

What is claimed is:
 1. A computer implemented method for monitoring atrend in heart failure (HF) progression, the method comprising: sensingventricular activation events at multiple ventricular sensing sites,where the activation events are generated in response to an intrinsic orpaced ventricular event; implementing program instructions on one ormore processors for automatically: identifying a morphology pattern (MP)for cardiac signals associated with the activation events; repeating thesensing and identifying operations, at select intervals, to build a MPcollection; and calculating an HF trend based at least in part on the MPcollection.
 2. The method of claim 1, further comprising classifying apatient condition based on the HF trend to form an HF assessment.
 3. Themethod of claim 1, wherein the performing further comprises determininga conduction pattern (CP) across the sensing sites based on theactivation events, the repeating building a CP collection and thecalculating calculates the HF trend based on the CP collection and theMP collection.
 4. The method of claim 1, wherein the sensing sites areleft ventricular sensing sites and the sensing comprises sensing leftventricular (LV) activation events at the multiple LV sensing sites. 5.The method of claim 1, wherein the calculating the HF trend comprisescalculating an MP-based trend indicator and a conduction pattern(CP)-based trend indicator, and the method further comprising comparingthe CP-based and MP-based trend indicators to corresponding thresholdsto classify the patient condition as one of improved, deteriorated or nochange.
 6. The method of claim 1, wherein the sensing and identifyingoperations are performed by an implantable medical device, while atleast a portion of the calculating operation is performed by at leastone of an external device and a remote server.
 7. The method of claim 1,wherein the sensing, identifying and classifying operations areperformed by an implantable medical device, the method furthercomprising transmitting the HF trend from the implantable medical deviceto at least one of an external device and a remote server.
 8. A methodcomprising: implementing program instructions on one or more processorsfor automatically: obtaining a morphology pattern (MP) collection ofmorphology patterns across multiple ventricular sensing sites; andcalculating an HF trend based on the MP collection.
 9. The method ofclaim 8, further comprising classifying a patient condition based on theHF trend to form an HF assessment.
 10. The method of claim 8, whereinthe method is a computer implemented method for monitoring a trend inheart failure (HF) progression in connection with left ventricular (LV)activation events sensed, over a select interval, at multiple LV sensingsites along a multi-electrode LV lead, where the activation events aregenerated in response to an intrinsic or paced ventricular event. 11.The method of claim 8, further comprising obtaining a conduction pattern(CP) collection of conduction patterns for cardiac signals associatedwith activation events, the calculating including calculating the HFtrend based on the MP collection and the CP collection.
 12. The methodof claim 8, wherein the obtaining the MP collection comprises at leastone of i) accessing memory of an external device or remote server thatstores the MP collection, ii) receiving the MP collection over awireless communications link between an implantable medical device and alocal external device, or iii) receiving the MP collection at a remoteserver over a network connection.
 13. A system, comprising: electrodesconfigured to sense ventricular activation events at multiple sensingsites, where the activation events are to be generated in response to anintrinsic or paced ventricular event; memory to store programinstructions, and one or more processors that, when executing theprogram instructions, are configured to automatically: identifying amorphology pattern (MP) across the sensing sites based on the activationevents; repeat the sensing and identifying operations, at selectintervals, to build an MP collection; and calculate an HF trend based onthe MP collection.
 14. The system of claim 13, wherein the one or moreprocessors are configured to classify a patient condition based on theHF trend to form an HF assessment.
 15. The system of claim 13, whereinthe one or more processors are configured to identify a conductionpattern (CP) for cardiac signals associated with the activation events,repeat the identify operation to build an CP collection and calculatethe HF trend based on the CP collection and the MP collection.
 16. Thesystem of claim 13, further comprising an implantable medical device(IMD) coupled to a multi-electrode LV lead, and a local external deviceconfigured to wirelessly communicate with the IMD, the local externaldevice configured to communicate over a network with a remote server,the one or more processors comprising at least a first processor housedwithin the IMD and configured to perform the identifying operation. 17.A system, comprising: electrodes configured to sense ventricularactivation events at multiple sensing sites, where the activation eventsare to be generated in response to an intrinsic or paced ventricularevent; memory to store program instructions, and one or more processorsthat, when executing the program instructions, are configured toautomatically: obtain a morphology pattern (MP) collection of morphologypatterns across multiple ventricular sensing sites; and calculate an HFtrend based on the MP collection.
 18. The system of claim 17, whereinthe one or more processors are configured to classify a patientcondition based on the HF trend to form an HF assessment.
 19. The systemof claim 17, further comprising an implantable medical device (IMD)comprising: sensing circuitry coupled to the electrodes to sense theventricular activation events; and the memory and the one or moreprocessors to automatically obtain the MP collection.
 20. The system ofclaim 19, wherein the one or more processors, of the IMD, are furtherconfigured to automatically calculate the HF trend, a transceiver of theIMD configured to transmit the HF trend from the IMD to at least one ofan external device and a remote server.